Discovery of Aminopiperidine Indoles That Activate the Guanine Nucleotide Exchange Factor SOS1 and Modulate RAS Signaling | Journal of Medicinal Chemistry
A New Dimension to Ras Function: A Novel Role for Nucleotide-Free Ras in Class II Phosphatidylinositol 3-Kinase Beta (PI3KC2β) Regulation | PLOS ONE
Phosphorylation promotes binding affinity of Rap-Raf complex by allosteric modulation of switch loop dynamics | Scientific Reports
The Activation of RalGDS Can Be Achieved Independently of Its Ras Binding Domain: IMPLICATIONS OF AN ACTIVATION MECHANISM IN Ras EFFECTOR SPECIFICITY AND SIGNAL DISTRIBUTION - ScienceDirect
Molecular recognition of RAS/RAF complex at the membrane: Role of RAF cysteine-rich domain | Scientific Reports
Simulating Ras: 30 years of progress - NCI
The current state of the art and future trends in RAS-targeted cancer therapies | Nature Reviews Clinical Oncology
Binding of active Ras and its mutants to the Ras binding domain of PI-3-kinase: A quantitative approach to KD measurements - ScienceDirect
The Ras switch in structural and historical perspective
Mapping the functional versatility and fragility of Ras GTPase signaling circuits through in vitro network reconstitution | eLife
RAS(ON) Inhibitors | Revolution Medicines
Raf promotes dimerization of the Ras G-domain with increased allosteric connections | PNAS
Integrated RAS signaling defined by parallel NMR detection of effectors and regulators | Nature Chemical Biology
Cancers | Free Full-Text | Cutting the Brakes on Ras—Cytoplasmic GAPs as Targets of Inactivation in Cancer
Raf promotes dimerization of the Ras G-domain with increased allosteric connections | PNAS
Structural Insights into the BRAF Monomer-to-dimer Transition Mediated by RAS Binding | bioRxiv
RAS(ON) Inhibitors | Revolution Medicines
Modeling the Role of G12V and G13V Ras Mutations in the Ras-GAP-Catalyzed Hydrolysis Reaction of Guanosine Triphosphate | Biochemistry
The Ras switch in structural and historical perspective
RCSB PDB - 1U8Y: CRystal structures of Ral-GppNHp and Ral-GDP reveal two novel binding sites that are also present in Ras and Rap
The Ras switch in structural and historical perspective
Structures of Gα Proteins in Complex with Their Chaperone Reveal Quality Control Mechanisms
